Nett Lab Publications

  • (13) Emerging functions within the enzyme families of plant alkaloid biosynthesis

    Fabiola Muro-Villanueva & Ryan S. Nett
    Phytochem Rev. (2023).DOI: 10.1007/s11101-023-09901-z

Ryan's postdoc and grad school work

  • (12) Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis

    Ryan S. Nett*, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, & Elizabeth S. Sattely* (*co-corresponding authors)
    Nature. (2023). 624, 182-191. DOI: 10.1038/s41586-023-06716-y

    --Highlight in MCB Department News - Plants Repurpose a Textbook Enzyme to Build Neuroactive Alkaloids

    --News & Views summary in Nature Plants - Assembling neuroactive alkaloids

    --Spotlight in Journal of Plant Physiology - Alpha carbonic anhydrases join the club of alkaloid biosynthetic enzymes

    --Spotlight in Molecular Plant - Plant gene co-expression defines the biosynthetic pathway of neuroactive alkaloids


  • (11) Production of the plant hormone gibberellin by rhizobia increase host legume nodule size

    Ryan S. Nett, Kelly Bender, & Reuben J. Peters
    The ISME Journal. (2022). 16, 1809-1817. DOI: 10.1038/s41396-022-01236-5

  • (10) Total biosynthesis of the tubulin-binding alkaloid colchicine

    Ryan S. Nett & Elizabeth S. Sattely
    JACS. (2021). 143(46), 19454-19465. DOI: 10.1021/jacs.1c08659

  • (9) A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis

    Ryan S. Nett, Yaereen Dho, Yun-Yee Low, & Elizabeth S. Sattely
    PNAS. (2021). 118 (24), e2102949118. DOI: 10.1073/pnas.2102949118

  • (8) Discovery and engineering of colchicine alkaloid biosynthesis

    Ryan S. Nett*, Warren Lau, & Elizabeth S. Sattely (*equal contribution)
    Nature. (2020) 584, 148-153. DOI: 10.1038/s41586-020-2546-8

    --News & Views in Nature - How the flame lily synthesizes a therapeutic natural product

    --Highlight in ChemMedChem - Puzzling Out the Colchicine Biosynthetic Pathway

    --Chembites article summary - An alternative to isolating plant drugs

  • (7) Unraveling a tangled skein: evolutionary analysis of the bacterial gibberellin biosynthetic operon

    Ryan S. Nett, Huy Nguyen, Raimund Nagel, Ariana Marcassa, Trevor C. Charles, Iddo Friedberg, & Reuben J. Peters
    mSphere. (2020) 5 (3), e00292-20. DOI: 10.1128/mSphere.00292-20

  • (6) D2O labeling to measure active biosynthesis of natural products in medicinal plants

    Ryan S. Nett*, Xin Guan*, Kevin Smith*, Ann Marie Faust, Elizabeth S. Sattely, & Curt R. Fischer (*equal contribution)
    AIChE Journal. (2018) 64 (12), 4319-4330. DOI: 10.1002/aic.16413

  • (5) A third class: Functional gibberellin biosynthetic operon in beta-proteobacteria

    Raimund Nagel, John E. Bieber, Mark G. Schmidt-Dannert, Ryan S. Nett, & Reuben J. Peters
    Frontiers in Microbiology. (2018) 9, 2916. DOI: 10.3389/fmicb.2018.02916

  • (4) An operon for production of bioactive gibberellin A4 with wide distribution in the bacterial rice leaf streak pathogen Xanthomonas oryzae pv. oryzicola

    Raimund Nagel, Paula C.G. Turrini, Ryan S. Nett, Jan E. Leach, Valérie Verdier, Marie‐Anne Van Sluys, & Reuben J. Peters
    New Phytologist. (2017) 214 (3), 1260-1266. DOI: 10.1111/nph.14441

  • (3) Characterization of CYP115 as a gibberellin 3-oxidase indicates that certain rhizobia can produce bioactive gibberellin A4

    Ryan S. Nett, Tiffany Contreras, & Reuben J. Peters
    ACS Chemical Biology. (2017) 12 (4), 912-917. DOI: 10.1021/acschembio.6b01038

  • (2) Labeling studies clarify the committed step in bacterial gibberellin biosynthesis

    Ryan S. Nett, Jeroen S. Dickschat, & Reuben J. Peters
    Organic Letters. (2016) 18, 5974-5977. DOI: 10.1021/acs.orglett.6b02569

  • (1) Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

    Ryan S. Nett, Mariana Montanares, Ariana Marcassa, Xuan Lu, Raimund Nagel, Trevor C. Charles, Peter Hedden, Maria Cecilia Rojas, & Reuben J. Peters
    Nature Chemical Biology. (2017) 13, 69-74. DOI: 10.1038/nchembio.2232